Two distinct case reports with foamy cell and differential diagnosis: Xanthomatous meningioma and review of literature

Meningiomas are the most common primary intracranial tumor thought to derived from arachnoidal cap cells in meningeal coverings of spinal cord and brain. The current WHO classification, published 2016, includes nine different subtypes grade 1 meningiomas, three 2 3 meningiomas. Metaplastic meningioma is a rare variant which shows focal or diffuse mesenchymal tissue component. Xanthomatous has foamy cell changes quite metaplastic meningioma. Two patients, 54 59 years old, who applied our clinic with similar symptoms, were operated for Histopathological examination their biopsy showed that neoplastic had oval-round nuclei eosinophilic cytoplasm. In xanthomatous meningioma, some clear vacuolated cytoplasm (foamy cells). microscopic resection material one these areas These scattered among other meningothelial they positive EMA. To best knowledge, until today there have been only 14 reported cases English literature. Here, we aimed discuss pathogenesis differential diagnosis two